Due to a number of players entering the AFL's Health and Safety protocols, the West Coast Eagles' match against St Kilda will not proceed as planned.

The round four game, scheduled for SkyBus Stadium in Melbourne Friday evening, will be re-fixtured because the Eagles have limited player availability.

The club was unable to meet the minimum team requirements of 16 primary listed players and five top-up players as per the AFLW COVID Match Rescheduling Guidelines.

The players' health and safety remains paramount, with the club working closely with the AFL and Victorian Government to ensure the team's wellbeing is the first priority.

"Despite our best efforts and controls several staff and players are now isolating within our Melbourne accommodation under AFL Health and Safety protocols," General Manager of Community and Game Development, Richard O'Connell said.

"We are continually monitoring the health and wellbeing of all players and staff, I’m pleased to report all are in good spirits and not requiring medical support.

"This, combined with injuries and a suspension has significantly impacted our player availability for the match against St Kilda.

"Collectively we are disappointed not to be able to take the field and show our supporters how hard we have been working to learn from our past games, but player/staff health and wellbeing remains our key priority.

"We thank St Kilda for their understanding regarding the postponement, and look forward to playing them when the AFL reschedule our match.

"Thank you to our supporters, partners and well-wishers – the travel party value and appreciate the messages we are receiving and it’s fantastic to know they have our backs."